Lesson eight CBD research on health conditions. Since the discovery of the endocannabinoid system research has been done continuously on the benefits of CBD until the US deregulated him in 2018. It was virtually impossible for researchers who do adequate clinical studies on the effects of CBD on human subjects. However, the thousands of research studies is very promising. Here's a review of some studies that have been done on various health conditions and CBD, CBD and anxiety. One of the best ways to assess stress or fear in the body is to measure cortisol levels in the blood.
Cortisol is one of the key hormones involved in inflammation and stress. A group of Brazilian researchers investigated the effect of CBD doses on cortisol levels in humans and found that CBD significantly decreases cortisol levels. Social Anxiety is a medical term for people who are nervous in social situations. CBT has been shown to reduce anxiety in people with social anxiety disorder, and it may also be effective for panic disorder, obsessive compulsive disorder, and PTSD. One group of researchers studied the effects of the simulated public speaking test on healthy control people who took either CBD or a placebo 90 minutes before making a speech. These people had never been treated for social anxiety.
The results showed that those people who took CBD improve their speech performance and significantly decrease their stress when anticipating their speech. The placebo group showed greater anxiety, cognitive impairment and discomfort. Further, they did MRI scans of the subject afterwards, it revealed that CBD triggers activity in the areas of the brain that are linked to anxiety and emotion. CBD and blood pressure. CBD is a known vasodilator that can be beneficial in the management of blood pressure. In a recent study nine healthy male volunteers were given 600 milligrams of CBD or a placebo.
In a randomized placebo controlled double blind crossover study. subjects who had taken CBD had lower blood pressure, especially before and after stress, CBD and bone health. The effect of CBD on bones is demonstrated by a 2015 study that investigated the properties of cannabidiol. In relation to bone related conditions. The researchers studied the effects of CBD and THC on bone fracture healing by using both cannabinoids separately and then by mixing the two compounds in equal amounts. The research found that mice treated with CBD and improved bone healing the data analysis and biochemical testing showed that CBD enhanced callus strength and toughness of the bone, CBD in cancer.
We all have cancer cells in our bodies at any time, these cells proliferate depending on the health of our immune systems. The way the body eliminates them is through a process called apoptosis, which is damaged cell suicide. If the process of a pop ptosis fails, the mutated cells can duplicate rapidly and invade the adjacent cells, which is what we call cancer. When our immune systems are healthy, they can recognize damaged cells and trigger a pop ptosis. One of the most exciting areas of research on CBD is its effect on cancer. There are a lot of studies on CBD and how it protects the body against cancer.
In one study, investigators found that CBD protected DNA from oxidative damage and increased Endocannabinoid levels. The National Cancer Institute details Several studies into the anti tumor effects of CBD. Another critical issue when it comes to the treatment of cancer is its effect on the reaction to chemotherapy. CBD has been shown to ease nausea and vomiting. Researchers have found it in low doses, it suppresses toxin induced vomiting. So low doses of CBD are enough to ease the nausea from chemotherapy, CBD and diabetes.
A 2006 study found that CBD treatment significantly reduced the incidence of diabetes in non obese diabetic mice from an incidence of 86% in non treated mice to an incident of 30% in CBD treated mice, that's a 56% reduction CBD in the heart. A review of the literature in the British Journal of Clinical Pharmacology suggests several benefits to the cardiovascular system when taking CBD oil recently Teachers found that CBD relaxes blood vessels so blood can flow more easily. CBD also protects against heart tissue damage caused when the blood supply returns to the tissue after a period of a shamea, which is a lack of oxygen and against cardiomyopathy, like an enlarged heart or other heart tissue damage associated with diabetes, CBD and neurodegenerative conditions. animal models have clearly established the role of the endocannabinoid system in multiple sclerosis. Research has shown that there are significant deficits in inand amide and to Ag in the cerebral spinal fluid of people with MS.
In Huntington's Disease Research. A mouse model demonstrated a widespread impairment of Endocannabinoid function due to reduced numbers of Endocannabinoid receptors. In addition, the postmortem brains of human patients with Huntington's showed a striking loss of immunity reactivity of CB one, this loss could be the reason for reduced levels of GABA. These reductions range from 15% in the cerebellum up to 25% in the frontal cortex confirming under activity of the endocannabinoid system in Huntington's that would disrupt neuro transmission in correlated inversely with disease severity. Direct laboratory measurements were also performed in the cerebral spinal fluid of untreated Parkinson's disease patients. They show a doubling of banana amide levels over age match controls, irrespective of disease stage.
The author suggested that this is a compensatory mechanism to alleviate dopamine depletion. Clearly there is a relationship between dopa main and CBD, CBD and opioid addiction. CBD has been shown to connect to the same brain synapses as opioids. This is big news, because we used in conjunction with an opioid CBD will reduce the likelihood of opiate dependence. A recent study published in the American Journal of Psychiatry showed that CBD in contrast to a placebo significantly reduced both craving and anxiety in heroin addicts. These double blind, randomized placebo controlled trial assess the effects of CBD on anxiety and craving and drug abstinent individuals with heroin use disorder.
CBD continued to show significant effects on these measures seven days after the three days CBD exposure, CBD for pain and inflammation when it comes to anti inflammatory effects, CBD is a clear winner over drugs. A pro inflammatory cytokine is a type of signaling molecule that is excluded from immune cells and certain other cell types that promote inflammation a 2006 studies showed a significant reduction of blood levels of pro inflammatory cytokines when using CBD. So CBD reduces the levels of inflammation in the body. Externally, it can be used as a topical ointment that relieves nerve pain and tingling in hands and feet. further studies suggest that CBD oil can reduce arthritis pain. A 2012 study published in the Journal of Experimental Medicine found that CBD significantly suppressed chronic inflammatory and neuropathic pain in rodents without causing analgesic tolerance.
In other words, you don't need to continue to increase the dose to get a response. CBD in psychosis, psychosis is a loss of contact with reality. research in this area shows that CBD has a pharmacological profile like that of certain anti psychotic drugs. People with psychotic episodes regularly show signs of endocannabinoids deficiency, they have fewer CB two cannabinoid receptors than do healthy people. They also have lower levels of the enzyme so that enable the endocannabinoid system to function properly. In one study and and amide levels were eight fold higher in the cerebrospinal fluid of untreated acute schizophrenia.
Then in controls, CBD and PTSD, recent research in humans has clarified the role of the endocannabinoid system in post traumatic stress disorder. In one study, 46 survivors of the World Trade Center attacks were studied. The serum to ag levels were significantly reduced into PTSD victims versus those without PTSD symptoms. The research suggests a good correlation of lower serum and Nanda mine levels to increased CB one receptor binding sites in the central nervous systems of the untreated PTSD patients. Bye bye Measuring cortisol levels in a Nanda mine together, researchers were able to correctly identify 85% of the PTSD cases. In addition, they found that women had a greater susceptibility to the development of PTSD, CBD and seizures.
Epilepsy is a condition that is shown a particularly beneficial response to CBD. a 2014 survey conducted at Stanford University was given to parents belonging to a Facebook group dedicated to sharing information about the use of cannabidiol and rich cannabis to treat their child's seizures. There was an average of 12 anti epileptic drugs tried before using CBD 84% of the parents reported a reduction in their child's seizure frequency while taking CBD. Later in 2014. Researchers reported on preliminary results of a study involving children with treatment resistant epilepsies People received a purified 98% rich CBD extract. After three months of treatment 39% of the subjects had greater than 50% reduction in their seizures.
This research led to the development of EPA dialects, a CBD based drug for the treatment of epilepsy. These are just some of the studies that have been done on CBD and health related conditions. For further research. Please go to pub med