Today we'll talk about the drug therapies used to help people quit primarily bupropion. The trade name is IBM veranda clean, the trade name is Champix or Chantix, and cytosine. And at the end of this video, we'll we'll just talk a little bit about electronic cigarettes. bupropion was first studied in the treatment of depression, and it's still marketed as an antidepressant under the name of Wellbutrin. While not a nicotine replacement therapy, like the energies in discussed in the previous video, it does have some usefulness and reducing withdrawal symptoms in people who would like to quit smoking. bupropion or Zyban, which is the trade name blocks the uptake of dopamine which is released when we inhale nicotine or take nicotine and it non competitively inhibits the brains and nicotine receptors in many Teens levels of dopamine in the reward centers of the brain.

While effects levels of norepinephrine, a chemical known to be associated with the development of the symptoms of withdrawal, its use has been shown to double the success rate of a quit. The usual dose of bupropion or sigh ban is to start with 150 milligrams daily for three days, then increase to 150 milligrams twice a day. It is recommended to pick a quit date one week after therapy is started. The most common side effects with bupropion is insomnia, relieved by taking the second dose of the day at least eight hours before bedtime. Dry mouth nausea or headache can also occur and rarely seizures. Did continuations were mostly due to tremors and rashes.

It should be noted that bupropion should not be used individually With seizure or eating disorders, or in those with conditions that could potentially lower the seizure threshold, such as when withdrawing from alcohol or benzodiazepines. If there's any uncertainty though, a pharmacist or physician or nurse can provide additional information and guidance about your choices. bupropion inhibits liver enzymes, which can affect the metabolism of other medications and interact with their effectiveness. Again, double checking with a pharmacist to be sure there are no interactions before starting to bupropion would be very wise for Rana clean or Champix in Canada, and Chantix in the USA binds to nicotinic receptors in the brain, releasing some of the dopamine but not as much as the cigarette would. But it also binds to the receptor so strongly that if a cigarette is smoked while on the veranda clean, there is nowhere for the nicotine to go and there You don't get the same smoking satisfaction as you would normally get from the cigarettes without the Rana clean on board.

The odds ratio of quitting with Breanna clean is approximately three to one. Rana clean dosing should start one to two weeks before a quit date is that the initial dose is point five milligram once daily for the first three days. Then you increase 2.5 milligram twice a day for the next four days. Then one milligram twice a day for the duration of therapy for any claim should be taken with food and with a full glass of water. Therapy should continue for at least 12 weeks, but even longer if required. When it's time to discontinue the therapy tapering could be considered.

Lower doses are recommended in those with reduced kidney function. And in those who experience lots of nausea on the folder. The most common side effects with Rana clean is no Yeah, but taking the drug with food and lots of water will address this in most cases. There can also be some Mauldin's Omnia, fatigue and dizziness, but those side effects are quite rare. Both bupropion and Brandon clean require a prescription. There are pros and cons to each.

For example, bupropion clock causes less weight gain, is more beneficial in depression, and is a little bit less expensive, however, should not be used in reduced kidney or liver function with a history of seizures, and has quite a few drug interactions to consider. Rana clean has slightly better long term quit rate. It's safer to use in reduced kidney function, but is less safe and uncontrolled mood disorder. cytosine is a plant derived alkaloid that has been around for a long time. It is just regaining popularity however, as a quit smoking aid Like for Anna clean site Athena's structurally similar to nicotine, and a binds to the nicotinic receptors to cause a small release of dopamine, reducing the severity of withdrawal symptoms and reducing the reward and satisfaction associated with smoking. cytosine is available over the counter or by prescription depending on where in the world you live.

It can also be ordered over the internet. But the usual dose is at 1.5 milligram tablet and as a tapering dose over 25 days. You start with one tablet every two hours on day 123, which is about nine milligrams a day. And you taper down to one tablet every six hours on day 21 to 25 or three milligrams a day. The goal is to decrease the number of cigarettes smoked over the first five days of therapy with a recommended quit day on day five. However, There really is no published data to confirm this.

Cytosine has a really short Half Life compared to veranda clean even though they're very similar drugs, and it's not metabolized, it is readily absorbed through the stomach and excreted by the kidneys, therapies appears to be very few drug interactions and little penetration of the drug into the central nervous system. So cytosine is well tolerated at the recommended dose, with few adverse effects noted. If anything side effects were mostly stomach related, such as nausea. One advantage of sight unseen is that it is really inexpensive and it can be purchased online without a prescription. In most cases, clinical trials are underway, but it has already been shown to provide superior results to a placebo or to to the nicotine replacement therapy. E cigarettes or electronic cigarettes are battery operated ones that contain liquid nicotine and or flavorings and other chemicals, which when he did emit an aerosol that can be inhaled or vapor.

Of all the available quit smoking aids, electronic cigarettes have gained the most popularity lately, likely because they're designed to simulate the smoking experience. I don't generally recommend the use of E cigs for the following various reasons. In my experience working with quit smoking clients, I am not aware of anyone who has been able to quit smoking using the e cig technology and in fact many of my clients continue to smoke cigarettes and use the e cig as well. Also eat all e cigs contain propylene glycol and this can be an irritant to the lungs especially if lung function is already compromised. And there is no combustion but whatever is in the cartridge is still limited to the air around the user of an e cig exposing others to whatever is in The cartridge and that is the big question what is in the cartridge there are no regulations regarding the electronic juice in the cartridges either and it really is the Wild West out there.

Cartridges are filled in back rooms or in suppliers basements and then sold to annoying customers. If you decide to order anything, please be cautious. They have not been confirmed to be safe and no electronic smoking products have been granted a market authorization in Canada by Health Canada. However, they are talking about creating some regulations around these devices. In summary, due to the relatively short history of E cigs, there are some unanswered questions about their long term health safety. Studies up to this point have suggested that vaping is safer than smoking because it does not expose the person to the inhaled toxins found in cigarette smoke that can cause cancer.

Is it safer than smoking? Very likely, but we still need to do more research. So I guess the main question is, are the e6 really helping people to quit smoking? A recent survey showed that the most frequent reason to use any cigarette was to quit smoking. Yet studies are showing that the device only modestly reduce the desire to smoke. And that's certainly what I'm seeing in my experience.

E6 containing nicotine in the cartridge can deliver a fatal dose of nicotine to children. And there does not appear to be any regulations around selling them to someone under 18. And this poses a risk of the starter product and use who have never smoked. There's a new Harvard University study that suggests East cigarette flavoring causes popcorn lung, Bronco lightest obliterates is called that because the condition first arose in staff who worked at factories that packaged microwave popcorn. Lead author Joseph Allen says it's caused by a car flavoring compound called diaster tail. recognition of the hazards associated with inhaling flavoring chemicals started with popcorn long over a decade ago.

However, diacetyl and other related flavoring chemicals are used in many other flavors beyond butter flavored popcorn including fruit flavors, alcohol flavors, and candy flavored e cigarettes. popcorn lung is characterized by a dry cough, shortness of breath and wheezing. It is permanent and can be life threatening. The Harvard study said there are more than 7000 flavored e cigarettes on the market. Damaging chemicals were detected in 47 of 51 sampled products. There's also heat not burn products or HMB products.

I heat not burned tobacco product heats tobacco to a lower temperature than when a conventional cigarette is burned. The reason Goldstein's smoke contains nicotine and other chemicals, but fewer chemicals because the tobacco is not actually burned. These products are being introduced by large tobacco companies. There is no reliable evidence that these products are any less harmful though, especially less harmful than a cigarette. And some tobacco companies claim they're less harmful. But this has really not been verified.

Heat not burn products first came to market in 1988. However, they were not a commercial success. There has been growing dissatisfaction with the electronic cigarettes because they don't give or provide this rotate that smokers are used to. And this dissatisfaction may present an opportunity for heat not burn tobacco products. research done on early HMV devices have shown exposure to higher levels of carbon monoxide than regular tobacco cigarettes. And so the jury is still out on whether these are actually safer products or not.

High quality objective research to evaluate electronic cigarettes and their reintroduced heat not burn products are really needed. And until then I would recommend that people who want to quit smoking with the addition of AIDS use products and techniques that are well researched. This includes nicotine replacement therapy, bupropion grana clean and cytosine of which have been extensively studied and partner with a health coach with special expertise in quit smoking. That alone will help you succeed.