This module begins with how to select a topic for initiating a thesis or clinical study. It provides tips on how you can keep getting a stream of excellent and novel ideas that can be taken forward and published. It also gives you a detailed description of how to do a good PubMed search keeping in mind “what has not been done” and customize PubMed for your own benefit. Lastly, it highlights the pros and cons of the various study designs and teaches you to select the best study design for your own study.