But I can hear you asking if excess incident leads to high serotonin, then how is it possible that this then leads to serotonin deficiency. This is a result of a protective mechanism that our cells have, in the same way that our cells become resistant to the constant exposure to insulin neurons through a process called hermus. And netic plasticity will begin to protect themselves from an overflow of a particular neurotransmitter and reduce the sensitivity to that neurotransmitter. So even though there is plenty of serotonin, the neurons are not actually reacting to the serotonin. In addition to this, the manufacture of neurotransmitters is not a simple linear flow. It requires other enzymes cofactors and meet order If a metabolic pathway such as tryptophan to serotonin becomes overused, the other cofactors such as vitamin B, for example, depletes leading to a slow or ineffective production of serotonin.
Also bear in mind that vitamin B three which is niacin, and nice and is a necessary co effect in the conversion of tryptophan into serotonin is also used in the metabolism of insulin. So in the case of a high carbohydrate diet, or when you're insulin resistant with is a certified incident, a great deal of nice and would have been used, that's already depleting the v3 reserves that may be necessary for serotonin production. So all of these are influencing factors and they're all affected the end result namely, depression and insulin and blood sugar. regulation is at the heart of all of this. Similarly, if one is hypoglycemic due to irregular or skipped meals, or too rigorous dieting. The result is a deficit of stored glycogen in the liver and muscles, low blood sugar and therefore low insulin.
Now, there is insufficient insulin to redirect the other amino acids away from the blood brain barrier. And then less tryptophan crosses the blood brain barrier to make serotonin and of course, you're going to have lycia return and then and to add to the mix, a low fuel intake will reduce your ATP stores and remember your ATP is your adenosine triphosphate. They are our little energy pockets. And as all metabolic pathways are very energy demanding, the available ATP will redirect towards your survival needs and away from C return and manufacture. All in all, the result is depression and low energy. Dopamine another neurotransmitter gives one the feeling of pleasure and reward.
Plus, dopamine is the precursor to adrenaline. So low dopamine results in a feeling of hopelessness because you've got low adrenaline and you've got the feeling of hopelessness, low motivation and a tendency to fly into a rage. Dopamine also needs the amino acid tyrosine. So too much incident would will direct a tyrosine away from the blood brain barrier. So, if we just have a look at a practical summary, meals that are higher in carbs will trigger insulin, and the result will be more serotonin and least opening. meals that are high in protein will favor tyrosine People who crave carbs often have an imbalance between insulin, serotonin and dopamine and may show depressive tendencies.
Balancing insulin and blood sugar will help to balance tryptophan and tyrosine